The vehicle-mounted drone defense system is a modified medium-sized mobile command and control platform based on the chassis of lightweight vehicles such as Coaster/Yutong. The vehicle-mounted equipment includes a control platform and modified vehicles based on radar, electro-optical and jamming equipment. The entire vehicle system is easy to operate, flexible and fast in deployment, and has a wide defensive range. It is a kind of combat attack equipment with omnidirectional attack equipment boasting active and passive detection and identification, automatic one-key deployment, "intelligent unattended" operation and other epoch-making features. It is particularly suitable for various scenarios such as areas prohibiting the flight and aerial filming of civil small drones (low, small and slow aircraft) around airports, sudden events, security scenes, important event sites, classified unit airspace, and various locations to prevent drones from falling and injuring people.